OUR GOAL IS TO TRANSLATE SCIENTIFIC ADVANCES IN RNA NANOTECHNOLOGY TO IMPROVE THE THERAPEUTIC OUTCOMES AND LIVES OF PATIENTS.

  • Our vision

    is to improve the life of patients through innovation in treatment and delivery of medicines by combining RNA nanotechnology and targeted drug delivery.

  • Our mission

    is to advance the development of safe and personalized therapeutics for patients with cancer and infectious diseases through providing expert technical services for the scientific community and innovative pharmaceutics for patients.

  • Our values

    are credibility, Integrity, and mutual trust and respect.

What We Do

ExonanoRNA LLC was established in 2017 in Columbus, Ohio to fill the need for commercial supply of high-quality RNA nanoparticles for research and pre-clinical studies. We have assembled a team of experienced scientists to efficiently coordinate a multidisciplinary effort in transitioning bio-nanotechnology, and especially RNA nanotechnology, from the bench to the clinic. We develop a broad range of innovative products in the primary area of RNA nanotechnology-based platforms for next generation targeted drug delivery and disease diagnosis.


RNA Nanotechnology has great promise to facilitate next generation pharmaceutical research and drug development. Based
on the pioneering work of Dr. Peixuan Guo’s research on RNA nanotechnology for more than 20 years
(https://rnanano.osu.edu/Guo/peixuanguo.html), RNA nanotechnology has shown to overcome limitations of conventional
cancer therapeutics and provide specific delivery of drugs (siRNA, miRNA and chemical drugs) with significantly enhanced
therapeutic effect and reduced toxicity and side effects.




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CAREERS

We are always looking to recruit talented scientists. The successful candidate will have a proven track record of
scientific productivity and ability to participate in a highly matrixed and innovative research environment.

  • Candidates must have a M.S. or Ph.D. degree with a strong background in RNA nanotechnology, molecular biology, RNA chemistry, RNA biochemistry or pharmaceutical sciences with focus on RNA.

  • Deep awareness and understanding of nanotechnology space for drug delivery and biologics.

  • Experience with formulation, development and deep understanding of nanoparticles is required.

  • Experience with process development and GLP/GMP production is a plus.

  • Experience with chemical conjugation, characterization techniques and analytical techniques is plus.

  • Excellent communication skills, both written and oral, and highly organized in terms of goal setting and achieving.

Interested candidates should send their CV and cover letter to hr@exonanorna.com .

Meet The Team


  • Yuri Nedialkov

    Senior Scientist


  • Jinqiang Chen

    Manager


  • Peixuan Guo

    Chair of Scientific
    Advisory Board


  • Mario Vieweger

    Vice president and
    Director for R&D


  • Feng.mei Pi, Ph. D.

    General Manager and
    Associate Director for R&D


  • Lora McBride

    Administrative Associate


  • Yuri Nedialkov

    Senior Scientist


  • Jinqiang Chen

    Manager


  • Peixuan Guo

    Chair of Scientific
    Advisory Board


  • Mario Vieweger

    Vice president and
    Director for R&D


  • Feng.mei Pi, Ph. D.

    General Manager and
    Associate Director for R&D


  • Lora McBride

    Administrative Associate

Administrative Assistant

The Administrative Assistant will work closely with the management team. Primary duties will include:

  • 1) Manages appointment calendars, assists with travel and meeting arrangements

  • 2) Work closely with the Administrative Associate, making aware of issues and concerns

  • 3) Will work with the Finance Team to ensure proper invoicing and payment

  • 4) Prioritize conflicting needs, and ability to work effectively with deadline pressures

  • 5) Prepares business agreement;

  • 6) Produces sales reports and presentations as needed

  • 7) High attention to detail and accuracy

  • 8) Promote a fun and team-oriented work environment


Required Experience:
Strong oral and written communication skills as well as organizational skills and attention to detail are a must. Candidate must have the ability to work on multiple projects simultaneously and have strong interpersonal and teamwork skills and to be flexible to changing priorities in a fast-paced environment. Excellent computer skills in Microsoft Office, Adobe Acrobat, Photoshop, and website design and maintenance; and critical thinking skills to judge independently and solve problem. Experience with Quickbooks a plus.
Bachelor’s degree in business administration, or related or similar experience.


Technician/Senior Technician in
RNA Nanotechnology
  • 1) Conduct day to day laboratory procedures, experiments and operate relevant instrument in a reliable manner with minimal supervision

  • 2) Conduct chemical synthesis and purification process of products

  • 3) Conduct characterization experiment and collect data

  • 4) Communicate effectively through written and oral means

  • 5) Contribute to all levels of research to support development of optimized nucleic acid therapeutics in multiple disease areas.

Required Experience:

  • 1) A B.S. degree or above in life science (preferably in chemistry) is required,

  • 2) Experience in nucleic acid chemistry or RNA biochemistry is preferred.

  • 3) Possess good laboratory skills relating to RNA biochemistry.

If you or your colleagues are interested in these positions, please feel free to contact us: mvieweger@exonanorna.com

For Investors

Advantages of RNA Nanoparticles for Therapy
  • -Negative charge disallows nonspecific permeation of negatively charged cell membrane

  • -Controlled synthesis provides defined structure and stoichiometry

  • -Multi-valency allows combination therapy and simultaneous targeting and detection

  • -Targeted delivery allows receptor mediated endocytosis

  • -Advantageous size (10 – 40 nm)

  • -Extended in vivo half-life (5-12 hr compared to 15-45 min for siRNA)

  • -Avoidance of antibody induction (protein-free) allows repeated treatment for chronic diseases

  • - Favorable pharmacokinetic profile in mice:

    • Half-life (T1/2) : 5-10 hr compared to 0.25-0.76 hr of siRNA counterpart;

    • Clearance (Cl): <0.13 l/kg/hr,

    • Volume of distribution (V(d)): 1.2 l/kg;

    • Does not induce interferon (IFN) response or cytokine production;

    • Repeated IV administrations of up to 30 mg/kg do not result in toxicity.

  • - RNA nanoparticles are classified as chemical drugs rather than biologics. This classification facilitates drug approval.