Developing a new class of RNA nanotechnology-based
therapeutics for cancer treatment

What We Do

Pharmaceutical R&D

Products and Services for RNA Nanotechnology

Pharmaceutical R&D

RNA Nanoparticle Delivery System (RNP)

Our RNA NanoParticle Delivery System (RNP) creates a unique nano-scaffold conjugated with small therapeutic RNA molecules and chemotherapeutic drugs that result in extraordinary pharmacokinetic and pharmacodynamic properties.

RNA NANOPARTICLE (RNP) PLATFORM:

  • The negative charge of RNP prevents nonspecific binding to cells
  • The defined structure and size (10-40nm) avoids immune system clearance
  • Targets tumors through enhanced permeability and retention (EPR) effect and by active targeting of ligands on RNP
  • Favorable pharmacokinetic profiles in mice:
    • T1/2: 5-10hr compared to 0.25-0.76hr of siRNA
    • Biodistribution: mainly in the tumor but no other healthy organs.
  • High delivery efficiency: ~5% compared to 0.7% using other nanoparticles
  • Low toxicity: no toxicity after repeated IV up to 30mg/kg in mice
  • Low immunogenicity: does not induce interferon or cytokine responses
RNA 4WJ Model

RNA Nanoparticles Displaying Exosomes Delivery System (ExRNA)

ExRNA exosomes deliver nucleic acid-based therapeutics to treat life-threatening diseases. We harnessed the natural delivery capabilities of exosomes and specific targeting properties of RNA nanoparticles to create a novel class of biotherapeutics.

ExRNA PLATFORM:

  • Displaying RNA nanoparticles on the exosome’s surface makes the ExRNA negatively charged, which prevents nonspecific binding to cells.
  • Displaying RNA nanoparticles with an aptamer or chemical ligand enhances its targeting efficiency.
  • ExRNA effectively delivers siRNA to the cell’s cytoplasm, escaping endosome trapping
  • Validated in mice model systems
Exosome Diagram

Products & Services for RNA Nanotechnology

Products

RNA nanoparticle model
RNA Nanoparticles

Aptamer-RNPs for specific cell-targeted delivery of miRNA/anti-miRNA

Exojuice-Box
Exojuiceâ„¢

For one-step large scale exosome purification with high purity

rna stock photo
RNA & DNA Oligos

High purity guaranteed Oligo delivery in as short as 5 days

chemRNA
ChemRNAâ„¢

Mutant T7 RNA Transcription kit, high yield guaranteed

Exosome Research
Exosome Research

RNA Nanoparticles-decorated exosomes for targeted siRNA delivery

Fraction Collector

Fraction Collector

Fits tubes from SW28 and SW55/50 rotors from Beckman Ultracentrifuge

Services

Exosomes:

✓  Quantification of Protein in
     Exosomes

✓  NTA-based Exosomes
     Characterization

✓  Quantification of RNA in
     Exosomes

✓  Custom siRNA Delivery via
     Exosomes

RNA Nano:

✓  Custom RNA Nanoparticles

✓  Custom Oligos

 

 

 

 

Cancer Research:

✓  Flow Cytometry-Based Cell
     Assays

✓  Confocal Microscopy-Based
     Cells Assay

You can also request our services via Science Exchange or Scientist.com

SE_Logo_Large
Scientist.com link

Our News

Footer-img
Logo