RNA Nanoparticles

Cancer Targeting

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miRNA Delivery

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RNA Nanoparticles for Exosome Decoration

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Custom RNA Nanoparticles

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Customized Products

Select a ligand for targeting for specific cancer cells and desired therapeutics moieties (miRNA, anti-miRNA, siRNA or chemical drug). We will prepare the required RNA Nanoparticle with high quality and in large scale for in vitro and in vivo studies.

Scaffold

Multi-Way Junction 2′-Fluoro RNA is highly thermodynamically and enzymatically stable and remains intact at ultra-low concentrations in blood circulation. It is an ideal scaffold for drug delivery. RNA scaffolds are available in various shapes and sizes.

Targeting Ligand

Nucleic acid-based aptamers and small chemical ligands can be conjugated to either termini of the scaffold to achieve specific targeting. The high thermodynamic stability of the junction scaffolds ensures correct folding and function of aptamers.

Therapeutic Module

Small nucleic acid-based therapeutic candidates, such as miRNA, anti-miRNA, siRNA, CpG DNA immune modulators, and chemical drugs can be easily conjugated to the junction scaffold, with authentic functionalities.

Imaging Module

Fluorescent or radioactive molecules can be conjugated to the scaffold as an imaging module. Near-infrared labeling of RNA nanoparticles allows for real-time monitoring of bio-distribution in vivo using IVIS imaging systems.

The thermodynamically stable 4WJ is the core structure of the multifunctional RNA nanoparticle. The structure has a Tm higher than 80°C and can keep undissociated at ultralow concentrations after being diluted as in blood circulation in vivo. This structure has been patented and licensed by ExonanoRNA for future drug development.

About RNA Nanotechnology

What is RNA Nanotechnology?

RNA nanotechnology is the study of nanometer-scale RNA architectures with their major frame being composed of RNA. The core scaffold, targeting ligand, regulatory moieties, and therapeutic modules can all be composed exclusively of RNA. RNA nanoparticles display the simplistic characteristic of DNA canonical base pairing while containing the structural flexibility and functional diversity characteristic of proteins. Noncanonical base pairing, base stacking, and elaborate networks of tertiary contacts increase RNA structure versatility while also increasing thermodynamic stability.

 

What is RNA Therapeutics?

RNA is well recognized as a prominent player in a variety of cellular processes. In fact, 98% of the human genome encodes for small or long noncoding RNAs, while only 2% codes for proteins. This abundance creates a wealth of structural RNA elements that can be used as building blocks for RNA nanotechnology, as well as a vast amount of targets for therapeutic intervention of disease. As a result, RNA is predicted to be the third milestone in drug development, including RNA nanoparticles, small therapeutic RNAs, and chemicals targeting RNAs.

 

RNA Nanoparticle Applications in Cancer Research

We provide a variety of RNA nanoparticle services and products in support of the RNA nanotechnology and therapeutics fields. Our RNA nanoparticle product lines are ideal to test:

1) efficacy of established targeting ligands on novel cell lines,

2) specificity of your novel targeting ligand on an established cell line,

3) efficacy of your novel therapeutic on an established drug delivery platform.

 

RNA Nanoparticle Product Lines

TrackRNA™ – TrackRNA are RNA nanoparticles designed for cell targeting research applications. This series of customizable RNA nanoparticles feature (a) a targeting ligand and (b) imaging modality to visualize binding specificity to cell receptors. These particles can be used to assay cell binding and uptake in confocal fluorescence, flow cytometry, in vivo biodistribution, or similar experiments.

NanoRNA™–NanoRNA are RNA nanoparticles designed for cancer therapeutics research applications. This series of customizable RNA nanoparticles contains (a) a targeting ligand and (b) a therapeutic modality to assay the therapeutic efficacy of novel targeting or therapeutic modalities. These particles are ideal to test cell uptake, endosome release, and therapeutic efficacy of your therapeutic payload.

ExoCoat™ – ExoCoat are RNA nanoparticles that feature (a) a cell specific targeting ligand and (b) a lipid anchor for exosome surface decoration. This product line transfers the targeting capabilities of RNA nanoparticles to exosomes which allows the cell specific delivery of large or sensitive cargo directly to the cell cytoplasm.

Custom RNA Nps – In addition to our standard product lines, we provide services for (a) RNA nanoparticle design, (b) RNA nanoparticle assembly, (c) RNA nanoparticle purification, and (d) RNA nanoparticle production.

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