Exosome Research

Exosome Research

  • RNA Nanotechnology
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Advantages of RNA Nanoparticles for Therapy
  • -Negative charge disallows nonspecific permeation of negatively charged cell membrane

  • -Controlled synthesis provides defined structure and stoichiometry

  • -Multi-valency allows combination therapy and simultaneous targeting and detection

  • -Targeted delivery allows receptor mediated endocytosis

  • -Advantageous size (10 – 40 nm)

  • -Extended in vivo half-life (5-12 hr compared to 15-45 min for siRNA)

  • -Avoidance of antibody induction (protein-free) allows repeated treatment for chronic diseases

  • - Favorable pharmacokinetic profile in mice:

    • Half-life (T1/2) : 5-10 hr compared to 0.25-0.76 hr of siRNA counterpart;

    • Clearance (Cl): <0.13 l/kg/hr,

    • Volume of distribution (V(d)): 1.2 l/kg;

    • Does not induce interferon (IFN) response or cytokine production;

    • Repeated IV administrations of up to 30 mg/kg do not result in toxicity.

  • - RNA nanoparticles are classified as chemical drugs rather than biologics. This classification facilitates drug approval.

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