What We Do
Pharmaceutical R&D
Products and Services for RNA Nanotechnology
Pharmaceutical R&D
RNA Nanoparticle Delivery System (RNP)
Our RNA NanoParticle Delivery System (RNP) creates a unique nano-scaffold conjugated with small therapeutic RNA molecules and chemotherapeutic drugs that result in extraordinary pharmacokinetic and pharmacodynamic properties.
RNA NANOPARTICLE (RNP) PLATFORM:
- The negative charge of RNP prevents nonspecific binding to cells
- The defined structure and size (10-40nm) avoids immune system clearance
- Targets tumors through enhanced permeability and retention (EPR) effect and by active targeting of ligands on RNP
- Favorable pharmacokinetic profiles in mice:
- T1/2: 5-10hr compared to 0.25-0.76hr of siRNA
- Biodistribution: mainly in the tumor but no other healthy organs.
- High delivery efficiency: ~5% compared to 0.7% using other nanoparticles
- Low toxicity: no toxicity after repeated IV up to 30mg/kg in mice
- Low immunogenicity: does not induce interferon or cytokine responses
RNA Nanoparticles Displaying Exosomes Delivery System (ExRNA)
ExRNA exosomes deliver nucleic acid-based therapeutics to treat life-threatening diseases. We harnessed the natural delivery capabilities of exosomes and specific targeting properties of RNA nanoparticles to create a novel class of biotherapeutics.
ExRNA PLATFORM:
- Displaying RNA nanoparticles on the exosome’s surface makes the ExRNA negatively charged, which prevents nonspecific binding to cells.
- Displaying RNA nanoparticles with an aptamer or chemical ligand enhances its targeting efficiency.
- ExRNA effectively delivers siRNA to the cell’s cytoplasm, escaping endosome trapping
- Validated in mice model systems
Products & Services for RNA Nanotechnology
Products
RNA Nanoparticles
Aptamer-RNPs for specific cell-targeted delivery of miRNA/anti-miRNA
Exojuiceâ„¢
For one-step large scale exosome purification with high purity
RNA & DNA Oligos
High purity guaranteed Oligo delivery in as short as 5 days
ChemRNAâ„¢
Mutant T7 RNA Transcription kit, high yield guaranteed
Exosome Research
RNA Nanoparticles-decorated exosomes for targeted siRNA delivery
Fraction Collector
Fits tubes from SW28 and SW55/50 rotors from Beckman Ultracentrifuge
Services
Exosomes:
✓ Quantification of Protein in
   Exosomes
✓ NTA-based Exosomes
   Characterization
✓ Quantification of RNA in
   Exosomes
Cancer Research:
✓ Flow Cytometry-Based Cell
   Assays
✓  Confocal Microscopy-Based
   Cells Assay
You can also request our services via Science Exchange or Scientist.com
Our News
Congratulate Dr. Peixuan Guo’s Induction into the National Academy of Inventors (NAI) Fellows Class of 2022
Dr. Peixuan Guo is attending the 12th NAI Annual Meeting (June 25-27, 2023) and Fellows Induction Ceremony at Washington DC. His name will be placed on a commemorative plaque on permanent display at the United States Patent and Trademark Office (USPTO) headquarters in...
Prof. Peixuan Guo as the Founder of ExonanoRNA LLC is Elected as the Fellow Member of the National Academy of Inventors
On December 8, 2022, Dr. Peixuan Guo, pioneer of RNA nanotechnology, discoverer of revolution motor, Sylvan G. Frank Endowed Chair Professor in Pharmaceutics and Drug Delivery in the College of Pharmacy at The Ohio State University is elected as a member of the...
ExonanoRNA Founder Receives the Ohio State University, 2021 Innovator of the Year Award
The prestigious award recognizes research, innovation, and entrepreneurial leadership Columbus, OH – April 15, 2021ExonanoRNA, LLC, today announced that Dr. Peixuan Guo, Chairman and Founder, has received the prestigious Innovator of the Year Award 2021 from the Ohio...